Biochemical and Other Mechanisms Associated With Olfaction and Taste Abnormalities in Covid-19

Loung V Umedani; Quratulain Javaid

Loung V Umedani
Quratulain Javaid

Keywords: Biochemical, neurological, manifestation, COVID 19, mechanisms.

Abstract

Coronavirus (SARS-CoV-2) spreads from its initial nasal reservoir to produce respiratory problems and
neurological manifestations. Viral spike protein-S binds with host receptor angiotensin-converting enzyme
2 with the assistance of membrane fusion protease. Average smell and taste disorders prevalence was 18.8%
and 14.1% respectively.
The objective of this narrative retrospective study was to explore mechanisms underlying olfactory and
gustatory manifestations. For obtaining novel information, we selected articles from January 2021 to January
2023. We searched terms like neurological manifestations, anosmia, loss of taste in COVID-19, and SARSCoV-2 as keywords using PubMed. After scrutiny, we excluded articles with accessory and non-relevant
information and finally selected 23 articles.
Various immune mechanisms like cytokine storm and direct neuroinvasions result in neurological manifestations.
Role of various micro RNAs in molecular pathology point towards future research to explore epigenetic
neuropathological mechanisms to help in designing novel therapeutic remedies. Global awareness and
vaccination protocols had greatly reduced occurrence of disease.
Key Words: Ageusia, anosmia, biochemical, COVID-19, mechanisms

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Biochemical and Other Mechanisms Associated With Olfaction and Taste Abnormalities in Covid-19

Mechanisms of olfaction and taste abnormalities in covid-19

Abstract

References