Phytomedicine Silybum marianum (Silymarin) as an Effective Hepato-protective source from nature

  • Huma Shareef IPS, JSMU
Keywords: Hepatic, Flavonolignans, Silybum marianum, Plant


Background: Silybum marianum is the most commonly prescribed phytomedicine for multiple Hepatic disorders. The common name of this plant is milk thistle. It exhibit its effects by the presence of flavonolignans via numerous mechanism the noteworthy are its antioxidant, anti- inflammatory and anti-fibrotic actions which make it suitable applicant for treatment of Liver fibrosis, cirrhosis, Fatty liver disease, Hepatitis, Hepatocellular carcinoma and many more. The drug is available mostly with the name of Silymarin in the market

Objective:  The aim of the present study is to unfold miracles of milk thistle to review its efficacy and safety for management in Hepatic disorders

Methodology: A thorough literature survey was carried out for the article. More than 50 articles were taken into consideration published between 2000 and 2018.

Result: The review exposed the main constituents of milk thistle and its properties to protect liver against various toxins, alcohol and viral attacks. Silymarin is capable to regenerate liver and bring the hepatic markers, AST, ALT and others, to normal levels and the reported toxicities of Silymarin are few.

Conclusion:  Silybum marianum has proved its higher efficacy and safety in Hepatic disorders, as compare to other therapies and therefore is an agent of choice. Furthermore its cost effectiveness and ability to be developed as various dosage forms, like emulsion and nanoparticles, undoubtedly ensures its extensive use in future.


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How to Cite
Shareef, H. (2019). Phytomedicine Silybum marianum (Silymarin) as an Effective Hepato-protective source from nature. Annals of Jinnah Sindh Medical University, 5(1), 39-46. Retrieved from