STATISTICAL ASSESSMENT OF DRUG RELEASE KINETICS AND FORMULATIONS ATTRIBUTES OF RANITIDINE TABLETS AVAILABLE IN KARACHI, PAKISTAN

  • Dr. Shaheen Parveen 1Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
  • Prof. Dr. Huma Ali Institute of Pharmaceutical sciences, JSMU
  • Maria sodagar 2Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan
  • Amber Nawab 3Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
  • Anum Tariq 2Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan
  • Dr. Fozia Israr 1Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
Keywords: Ranitidine, Weibull model, Dissolution profiles, physic-chemical, pharmaceutical

Abstract

In developing nations pharmaceutical formulations of same drugs may vary in their quality points of view. Such moieties offer elective decisions in individual social insurance deliverance setups with uneven estimating. Legitimizations of such items for treatment decisions are basically privileged of medication information gave by the maker and generally endure correlation points of interest of multisource items. Moreover drug release profiles of oral tablets likewise fundamentally essential in deciding the product unwavering quality in batch to batch framework. These investigations guarantee the items magnificence by observing distinctive products with equivalent remedial moieties. In the present study quality assessment including range of physic-chemical parameters was calculated for selected (six) brands of ranitidine (RT-1 to RT-6). Results were observed to be in satisfactory points of confinement. Additionally, disintegration profiles of all brands were resolved utilizing phosphate cradle pH 6.8. Information was investigated by a few factual strategies as recommended by FDA, for example, similarity factor (f2) and difference factor (f1) and one way ANOVA technique. Consequences of one – way ANOVA showed no huge distinction among the dissolution profiles of reference and test brands. Correspondingly, results of f1 and f2 showed similar profiles of test and reference products. In addition all the brands were found to be best fitted in Weibull model.

Author Biographies

Dr. Shaheen Parveen, 1Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan

Associate professor

Prof. Dr. Huma Ali, Institute of Pharmaceutical sciences, JSMU

Professor

Amber Nawab, 3Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

Assistant Professor

Anum Tariq, 2Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan

Assistant Professor

Dr. Fozia Israr, 1Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan

associate Professor

Published
2019-08-07