Diverse Histopathological Changes Due to Cholelithiasis Seen in Surgically Removed Gall Bladder Specimens
Objective: To review the diverse histopathological changes found in the cholecystectomy specimens operated for gallstones
Methodology: The study was conducted at surgical ward No. 26 of JPMC for 5 years from January 2012 to December 2017. As per policy, specimens from all patients with symptomatic gall stones who underwent cholecystectomy, were sent for histopathology, the reports were reviewed and frequency of different pathological changes were noted.
Results: We observed not merely chronic cholecystitis but a plethora of different histopathological changes including tuberculosis, premalignant conditions and carcinomas, with almost no suspicion of existing pathology pre-operatively.
Conclusion: This strengthens our belief that every gall bladder specimen should be subjected to histopathological examination.
William NS, O’Connell PR, McCoskie AW. Baily and love short practice of Surgery, 27th Edition. CRC Press. 2018;1198.
Zaki M, Al-Refeidi A. Histological Changes in the Human Gallbladder Epithelium associated with Gallstones. Oman Med J.2009;24(4): 269-73.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J. Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: A study of 8 cases, J. Am J Surg Pathol. 2013;37(8):1269-74.
LaMont JT, Smith BF, Moore JR: Role of gallbladder mucin in pathophysiology of gallstones; Hepatology.1984;4(5 Suppl):51S-56S.
Ibrahim H. Zahrani, Ibrahim Mansoor: Gallbladder pathologies and cholelithiasis. Saudi Med J. 2001;22 (10):88-89.
Khanna R, Chansuria R, Kumar M, Shukla H.S: Histological changes in gallbladder due to stone disease. Ind Journal Surg. 2006;68(4): 201-204.
Albores - Saavedra J, Molberg K, Henson DE. Unusual malignant epithelial tumors of the gallbladder. Semin Diagn Pathol.1996;13(4):326-38.
Palermo M, Núñez M, Duza GE, Dixon MG, Bruno MO, Trasitano FJ. Porcelain gallbladder: a clinical case and a review of the literature; Cir Esp. 2011;89(4):213–7.
Viny K, Abbas A, Fausto N ,Aster J. Robbin & Cotran Pathologic Basis of Disease, 8th Edition. Saunders.2010;1464.
Silk YN, Douglas HO, Nava HR, Driscole DL, Tartarian G. Carcinoma of the gallbladder. Ann Surg.1989;210(6):751-757.
Haq N, Khan BA, Imran M, Akram A, Jamal AB, Bangash F. Frequency of gall bladder carcinoma in patients with acute and chronic cholecystitis. J Ayub Med Coll Abbottabad. 2014;26(2):191-3.
Faisal GS, Nargis SS. An Audit of cholecystectomy specimens.Pak J Surg.2002;7(2):18-20.
Khalid SM. Pattern of gall bladder Diseases at NawabShah, analysis of 260 patients. Pak J Surg. 2006;22(4):212-14.
Samad A. Gall bladder carcinoma in patients undergoing Cholecystectomy for Cholelithiasis; J Pak Med Assoc, 2005;55(11):497-99.
Sanchiz Cardines EM, Humanes RS, Fernandez AL, Nieto RD, Suarez Munoz MA.Ectopic pancreas in gallbladder, clinical significance, Diagnostic and therapeutic Implications. Rev Esp Enferm Dig.2015;107(11): 701-703.
Shiwani MH, Gosling J. Hetrotropic pancreas of the Gall Bladder associated with chronic cholecystitis; J Pancreas.2008;9(1):30-32.
Albrose-saavedra J, Nadji M, Henson DE,Ziegels-weissman J, Mones JM. Intestinal metaplasia of the gall bladder a morphologic and immunocytochemical study. Hum Pathol.1986;17(6):614-620. doi: 10.1016/s0046-8177(86)80134-4
Khan MR, Raza SA, Ahmed Z, Naeem S, Pervez S, Siddiqui AA, et.al. Gallbladder intestinal metaplasia in Pakistani patients with gallstones; Int J Surg.2011; 9(6): 482-485.
Butt UI, Hameed B, Farooka MW, Ayyaz M, Chughtai A and Akbar MB. Tuberculosis of Gallbladder Mimicking Carcinoma. J Coll Physicians Surg Pak.2017;27(9):84-85.