Arsenic: A Cause of Cardiometabolic Syndromes

  • Aimen Umer khan Government College University Faisalabad
  • Khwaja Zafar Ahmed Principal, Jinnah College of Pharmacy, Sohail University
Keywords: Keywords: Arsenic, endothelial dysfunction, NO production, hypertension, atherosclerosis, hyperlipidemia, dyslipidemia.

Abstract

Background: Arsenic is an abundant toxic metal on earth. It is considered as major culprit of health for millions of people worldwide. The International Agency for Research on Cancer ranked arsenic as Group 1 carcinogenic agent. Arsenic ranked on top of the list of toxic substance according to The Agency for Toxic Substances and Disease Registry. The major source of toxicity of arsenic is via drinking water. The prevalence of arsenic- mediated toxicities has drastically increased in Asian population causing serious cardiovascular issues in animal and man from past few years.

Objectives: The objective of the present study is to identify major pathological biomarkers and their possible mechanism in Arsenic-induced cardiometabolic syndrome.

Methodology: The present review summarizes the data and literature taken from previously done studies from research gate, science direct, PubMed, PubMed Central, Medline, and some other scientific databases emphasizing the role of Arsenic in cardiometabolic syndrome. The results obtained through this database were assembled, composed, critically elucidated and presented in explanatory and tabular form.

Results: The major pathological target of Arsenic is antioxidant defense system and an increase in Reactive oxygen Species reduces Nitric oxide production, reduction in vascular permeability, increase adhesion and production of inflammatory mediators (IL-6, TNF-α,), TCs, TGs, LDL-C, lipid peroxidation, β-cells dysfunction. The persistent accumulation and generation of these pathological biomarkers in the blood vessels can induce hyperlipidemias, dyslipidemias, atherosclerosis, hypertension, and diabetes.

Conclusion: There arises a need to propose natural antioxidant with minimum side effects in the treatment of CMTs   

 

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Published
2020-12-31